EMIQ Activated Quercetin 60 Veggie Capsules

Feature Summary

Quercetin, a dietary flavonol known to be one of the most potent plant-derived antioxidants, has multiple biological actions, with preclinical studies showing anti-inflammatory, anti-thrombotic, and vasodilatory benefits.¹ The limiting factor in quercetin’s clinical efficacy appears to be its poor bioavailability. Enzymatically modified isoquercitrin (EMIQ) is a mixture of quercetin monoglucoside and its alpha-oligoglucosides that has been shown to have significantly greater bioavailability than other available forms. In animals, EMIQ was shown to produce a 40-fold increase in Cmax (peak plasma concentration) and an 18-fold increase in the area under the curve compared to quercetin.² In humans, EMIQ supplementation increased plasma concentrations to a significantly greater degree than other forms, including the aglycone and isoquercitrin (Q3G) forms.³ 

Randomized placebo-controlled trials have shown EMIQ to have clinical benefits not seen with less absorbable forms. In a recent crossover trial of volunteers at risk for cardiovascular disease (i.e., with elevated blood pressure, lipids, glucose, or waist circumference), EMIQ improved endothelial function (as measured by flow-mediated vasodilatation), a key risk factor for hypertension, atherosclerosis, and cardiovascular disease.⁴ American football players supplementing with whey protein had greater increases in lower limb muscle mass and antioxidant protection when consuming 42 mg of EMIQ per day compared to whey alone.⁵ Two trials found that EMIQ reduced medication use and ocular symptoms of hayfever due to Japanese cedar pollinosis.^6,7